Table 3 Correlation coefficients for gene expressions and clinical parameters and histological scores

From: Selective insulin resistance with differential expressions of IRS-1 and IRS-2 in human NAFLD livers

 

IRS-1

IRS-2

PEPCK

G6Pase

GCK

FAS

IR

Clinical parameters

  Body mass index (kg/m2)

0.06

−0.32a

0.34b

0.38a

0.13

0.17

−0.01

  AST (IU/L)

−0.18

−0.15

0.15

0.50a

0.25

0.14

0.26

  ALT (IU/L)

−0.09

−0.39a

0.30b

0.49a

0.27

0.11

0.09

  Total cholesterol (mg/dL)

−0.04

−0.15

−0.01

−0.13

−0.28b

−0.12

−0.18

  Triglycerides (mg/dL)

0.12

−0.13

0.26

0.25

0.05

0.08

−0.03

Histological scores

  Steatosis (0–3 points)

−0.17

−0.54a

0.38a

0.50a

0.11

0.04

0.39a

  Lobular inflammation (0–3 points)

−0.05

−0.35b

0.33b

0.59a

0.33b

0.22

0.35b

  Ballooning (0–2 points)

−0.07

−0.05

0.09

0.43a

0.10

0.13

0.24

  Fibrosis (0–4 points)

0.08

−0.15

0.30b

0.60a

0.19

0.19

0.44a

  1. Correlations between gene expressions and clinical biochemistry data were assessed employing Pearson’s test
  2. Correlations between gene expressions and the degrees of steatosis, lobular inflammation, ballooning and fibrosis were assessed employing Pearson’s test
  3. The data from 51 human liver biopsies are shown
  4. AST aspartate aminotransferase, ALT alanine aminotransferase, IRS-1 insulin receptor substrate-1, IRS-2 insulin receptor substrate-2, PEPCK phosphoenolpyruvate carboxylase, G6Pase glucose-6-phosphatase, GCK glucokinase, FAS fatty acid synthase, IR insulin receptor
  5. aP < 0.01
  6. bP < 0.05