Table 2 Hematologic characteristics and iron status biomarkers in normal weight (NW), overweight (OW), and obese (OB) Swiss women (n = 62)

From: Greater blood volume and Hb mass in obese women quantified by the carbon monoxide-rebreathing method affects interpretation of iron biomarkers and iron requirements

 

NW

OW

OB

OW/OB

n

24

19

19

38

Blood volume (mL/kg)b

74.9 ± 5.8d,e,f

64.3 ± 5.3e

59.4 ± 7.1

61.8 ± 6.7

Blood volume (L)b

4.59 ± 0.46d,e,f

5.10 ± 0.58

5.33 ± 1.01

5.21 ± 0.82

Plasma volume (mL/kg)b

46.6 ± 4.8d,e,f

40.1 ± 4.1

36.9 ± 4.9

38.5 ± 4.7

Plasma volume (L)b

2.86 ± 0.30d,e,f

3.17 ± 0.40

3.31 ± 0.66

3.24 ± 0.54

RBC (mL/kg)b

28.2 ± 2.1d,e,f

24.3 ± 2.6

22.4 ± 2.8

23.4 ± 2.8

RBC volume (L)b

1.74 ± 0.22d,e,f

1.93 ± 0.26

2.02 ± 0.39

1.97 ± 0.33

Hb (g/dL)b

13.5 ± 0.9

13.7 ± 1.2

13.7 ± 1.0

13.7 ± 1.1

Hb mass (g/kg)b

9.2 ± 0.7d,e,f

7.9 ± 0.8

7.3 ± 0.9

7.6 ± 0.9

Total Hb (g)b

566 ± 71d,e,f

627 ± 85

656 ± 126

641 ± 107

Serum iron (μg/mL)b

1.06 ± 0.44e

1.01 ± 0.35

0.75 ± 0.27

0.89 ± 0.33

Total serum iron (mg)b

3.02 ± 1.28e

3.14 ± 0.98e

2.50 ± 1.00

2.82 ± 1.03

TIBC (μg/mL)b

3.68 ± 0.66e

3.62 ± 0.66

3.17 ± 0.66

3.39 ± 0.69

Total TIBC (mg)b

10.5 ± 2.28

11.6 ± 3.00

10.3 ± 2.18

10.9 ± 2.66

Transferrin saturation (%)

29.8 ± 13.4

29.1 ± 12.1

24.6 ± 8.66

26.8 ± 10.6

sTfR (mg/L)c

6.61 (5.86, 7.45)

6.69 (5.82, 7.68)

7.00 (5.90, 8.30)

6.84 (6.16, 7.59)

Total sTfR (mg)c

18.8 (15.0, 21.5)f

21.1 (16.1, 27.4)

22.8 (15.6, 33.0)

21.9 (16.6, 28.7)

SF (µg/L)c

50.6 (40.2, 63.4)

59.9 (41.3, 86.8)

62.8 (45.4, 86.9)

61.35 (48.5, 77.6)

Total SF (mg)c

0.14 (0.10, 0.18)f

0.19 (0.11, 0.31)

0.20 (0.12, 0.35)

0.20 (0.13, 0.29)

Body iron (mg/kg)b

5.64 ± 2.70

5.92 ± 3.31

5.46 ± 3.10

5.70 ± 3.17

Serum hepcidin (ng/mL)b

9.20 ± 6.44

11.36 ± 6.73

12.48 ± 5.90

11.92 ± 6.3

Total hepcidin (µg)b

25.5 ± 17.6

35.4 ± 21.1

41.2 ± 21.5

38.3 ± 21.2

  1. Differences between NW, OW, and OB were assessed using one-way ANOVA with post hoc Bonferroni correction and Kruskal–Wallis test followed by independent samples Mann–Whitney U test corrected for multiple comparisons. Difference between NW and OW/OB was assessed with independent samples t-test. P-values < 0.05 were considered significant
  2. NW normal weight (BMI 18.5–24.9 kg/m2), OW overweight (BMI 25–29.9 kg/m2), OB obese (BMI 30–39.9 kg/m2), OW/OB overweight and obese (BMI 25–39.9 kg/m2), Hb Hemoglobin, TIBC total iron binding capacity, sTfR soluble transferrin receptor, IQR interquartile range.
  3. Values are: amedian (IQR), bmean (±s.d.), and cgeometric mean (95% confidence interval)
  4. dSignificantly different from overweight
  5. eSignificantly different from obese
  6. fSignificantly different from OW/OB
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