Table 3 Associations for composite risk score, non-adiposity risk score, and BMI from isotemporal substitutionof short to medium and long bouts of physical activity

	Composite risk score (n = 4338)			Non-adiposity composite risk score (n = 4338)^a			BMI (n = 38,232)
	Beta	95% CI	p-value	Beta	95% CI	p-value	Beta	95% CI	p-value
Medium bouts_500 cpm	−0.06	−0.035 to 0.025	0.68	−0.02	−0.043 to 0.011	0.25	0.103	0.071 to 0.135	<0.001
Long bouts_500 cpm	−0.03	−0.047 to −0.018	<0.001	−0.03	−0.040 to −0.013	<0.001	−0.02	−0.034 to 0.0002	0.052
Medium bouts_1000 cpm	−0.04	−0.075 to −0.003	0.03	−0.04	−0.070 to −0.002	0.04	−0.02	−0.061 to 0.019	0.29
Long bouts_1000 cpm	−0.04	−0.062 to −0.026	<0.001	−0.03	−0.046 to −0.012	0.001	−0.08	-0.100 to −0.058	<0.001
Medium bouts_2000 cpm	−0.04	−0.091 to 0.015	0.17	0.057	−0.222 to 0.336	0.69	−0.08	−0.136 to −0.022	0.006
Long bouts_2000 cpm	−0.01	−0.037 to 0.026	0.72	0.172	0.012 to 0.333	0.04	−0.07	−0.104 to −0.036	<0.001
Medium bouts_3000 cpm	0.081	0.003 to 0.158	0.04	0.105	0.032 to 0.177	0.005	−0	−0.089 to 0.081	0.92
Long bouts_3000 cpm	0.066	0.013 to 0.118	0.01	0.099	0.050 to 0.149	<0.001	0.022	−0.034 to 0.079	0.44

^aNon-adiposity composite risk score controlled for BMI
Beta-coefficients with 95% confidence intervals from linear mixed regression models. Coefficients are interpreted as holding the volume of physical activity above the respective threshold constant, but replacing 10 min of physical activity accumulated in shorter bouts (1-4 min) with 10 min of same intensity physical activity accumulated in the respective bout-duration (≥5–9 (medium) or ≥10 (long) minute bouts). Cpm counts/min, CI confidence interval, BMI body mass index

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