Fig. 1

Trajectories of risk factors over 20 years of follow-up according to weight/health status at baseline, estimated using multilevel models.
The multilevel models were adjusted for sex, ethnicity, baseline covariates (age, alcohol, smoking, mild and moderate exercise, occupational grade, GHQ, and diet), and medication at each assessment (for SBP, DBP, HDL-C, triglycerides, glucose, and HOMA-IR outcomes). MHNO N = 4371, MHO N = 272, MUNO N = 1487, MUO N = 399.
BMI body mass index, DBP diastolic blood pressure, GHQ general health questionnaire, HDL-C high-density lipoprotein cholesterol, HOMA-IR homeostatic model assessment of insulin resistance, MHNO metabolically healthy non-obese, MHO metabolically healthy obese, MUNO metabolically unhealthy non-obese, MUO metabolically unhealthy obese, SBP systolic blood pressure, WC waist circumference