Fig. 7

Effect of PTX3 deficiency on HFD-induced adipose inflammation a PTX3 protein expression and quantification in adipose tissues of WT mice by 12 weeks of high-fat diet (HFD) feeding. The age-matched mice fed regular chow diet (RCD) serve as controls. Male, RCD: n = 5, HFD: n = 6; Female, RCD: n = 7, HFD: n = 5. The values were mean ± SD for protein expression. b Body weight in WT and Ptx3-KO male and female mice during 12 weeks of HFD feeding. Male, WT n = 6, Ptx3-KO n = 8; Female, n = 8 per group. c Serum levels of adiponectin and mRNA expression in visceral adipose tissue of WT and Ptx3-KO male and female mice on HFD. Male, WT n = 6, Ptx3-KO n = 8; Female, n = 8 per group. d Proinflammatory (M1 marker) and anti-inflammatory (M2 marker) gene expression in visceral WAT of WT and Ptx3-KO male and female mice on HFD. The values were mean ± SEM for gene expression. *p < 0.05, **p < 0.01, ***p < 0.001 vs. WT; WT: wild-type; KO: knockout; WAT: white adipose tissue