Table 1 Sensitivity analysis of TEE. This analysis examines how potential nonadherence could influence the diet effect on TEE in the per protocol (weight stable) group, considering how FQ (used in DLW methodology) changes with macronutrient ratio

From: Scientific discourse in the era of open science: a response to Hall et al. regarding the Carbohydrate-Insulin Model

 

Degree of nonadherence (proportion of total)a

0%

10%

20%

30%

40%

50%

60%

FQ low-carbohydrate diet

0.7880

0.7938

0.7996

0.8054

0.8112

0.8170

0.8228

FQ high-carbohydrate diet

0.9040

0.8982

0.8924

0.8866

0.8808

0.8750

0.8692

TEE diet effectb

kcal/day

280c

249c

219c

188c

158c

127c

97

TEE diet effect

kcal/day per 10% decrease in carbohydrate

70

69

68

67

66

64

60

  1. aAssumes that any foods eaten off protocol for both low-carbohydrate (20% carbohydrate, 60% fat) and high-carbohydrate (60% carbohydrate, 20% fat) diet groups reflected the macronutrient composition of the moderate-carbohydrate (40% carbohydrate, 40% fat) diet group
  2. bDifference between low- and high-carbohydrate diet groups, minimally adjusted for cohort, as per analyses in BMJ [2]
  3. cRemained statistically significant at p ≤ 0.05
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