Fig. 1
a–e LocusZoom plot of the association signals in MC4R regions for BMI with confirmation of effect at upstream of MC4R as well as identification of a novel haplotype at MC4R. Best variant rs6567160 (P = 5.36 × 10−25, Beta = 0.37). a GWAS effect in Europeans. b GWAS effect in African Americans (AA). c GWAS effect in Asians. d GWAS effect in Hispanic ethnicity. e GWAS signal for all ancestries. Estimated recombination rates (from HapMap) are plotted in cyan to reflect the local LD structure. The variants surrounding the most significant variant are color-coded to reflect their LD with the index variant (taken from pairwise r2 values from the HapMap database per ancestry, www.hapmap.org). Regional plots were generated using LocusZoom (http://csg.sph.umich.edu/locuszoom).
