Table 1 (a) The demographic distribution of EMR-linked eMERGE cohorts. (b) BMI breakdown by age, sex, cohorts, known race, as well as ethnicity.

From: Evaluation of the MC4R gene across eMERGE network identifies many unreported obesity-associated variants

(a)

Total

Age

Female/Male

BMI—female/BMI—maleb

Adult

58.47 (SD = 15.98)

43904/32657

29.15 (SD = 7.35)/29.35 (SD = 5.70)

Pediatricsa

11.73 (SD = 5.92)

9547/11883

22.02 (SD = 7.36)/20.65 (SD = 6.34)

(b)

 

Race

Ethnicity

 

EA

AA

Asian

Hispanic

 

Female

Male

Female

Male

Female

Male

Female

Male

Adult

eMERGE-seq

Age

N = 6654, mean = 51.46, SD = 15.72

N = 4771, mean = 56.58, SD = 14.50

N = 710, mean = 49.48, SD = 17.32

N = 372, mean = 51.02, SD = 16.76

N = 855, mean = 47.81, SD = 11.86

N = 492, mean = 50.61, SD = 12.02

N = 664, mean = 47.60, SD = 15.55

N = 344, mean = 49.74, SD = 14.95

BMIb

Mean = 29.34, SD = 7.15

Mean = 29.48, SD = 5.69

Mean = 32.33, SD = 8.45

Mean = 29.13, SD = 6.09

Mean = 25.10, SD = 5.37

Mean = 26.53, SD = 4.12

Mean = 29.10, SD = 6.90

Mean = 28.93, SD = 5.65

eMERGE-GWAS

Age

N = 29440, mean = 59.36, SD = 16.07

N = 23847,mean = 63.14,SD = 14.26

N = 3707, mean = 50.46, SD = 15.57

N = 1555, mean = 54.31, SD = 14.64

N = 352, mean = 51.47, SD = 17.26

N = 230, mean = 54.07,SD = 17.26

N = 1130, mean = 49.73, SD = 17.09

N = 546, mean = 54.08, SD = 16.81

BMI

Mean = 28.74, SD = 7.14

Mean = 29.40, SD = 5.65

Mean = 32.65, SD = 8.43

Mean = 29.74, SD = 6.71

Mean = 24.58, SD = 5.18

Mean = 26.27, SD = 4.35

Mean = 30.27, SD = 6.85

Mean = 29.45, SD = 5.58

Pediatrics

eMERGE-seq

Age

N = 1484, mean = 15.05, SD = 4.40

N = 2008, mean = 13.41, SD = 4.90

N = 834, mean = 12.33, SD = 5.84

N = 1339, mean = 11.24, SD = 6.14

N = 44, mean = 14.35, SD = 6.02

N = 50,mean = 12.69, SD = 6.42

N = 95, mean = 14.07, SD = 5.82

N = 127, mean = 12.32, SD = 5.62

BMI

Mean = 22.88, SD = 6.56

Mean = 20.93, SD = 6.07

Mean = 23.76, SD = 9.65

Mean = 20.98, SD = 7.44

Mean = 20.94, SD = 4.65

Mean = 20.74, SD = 4.30

Mean = 23.96, SD = 7.62

Mean = 22.47, SD = 7.07

eMERGE-GWAS

Age

N = 4098, mean = 12.01, SD = 5.86

N = 5189, mean = 10.83, SD = 5.91

N = 2486, mean = 11.81, SD = 6.02

N = 2559,mean = 10.47, SD = 6.16

N = 115,mean = 9.51,SD = 6.61

N = 117, mean = 9.13, SD = 5.96

N = 225, mean = 12.65, SD = 5.70

N = 280, mean = 9.96, SD = 5.75

BMI

Mean = 21.10, SD = 6.80

Mean = 20.41, SD = 6.19

Mean = 22.60, SD = 7.65

Mean = 20.98, SD = 6.43

Mean = 18.24, SD = 4.09

Mean = 18.44, SD = 4.35

Mean = 22.89, SD = 7.57

Mean = 21.28, SD = 6.78

  1. BMI body mass index (kg/m2), SD standard deviation, EA European American, AA African American, eMERGE-seq participants from eMERGE network with MC4Rsequencing data, eMERGE-GWAS participants from network with whole-genome genotyping data.
  2. aDefined as ≤21 years old.
  3. bOverall mean and standard deviation (SD) of precalculated median body mass index (BMI) for each individual.
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