Table 1 Serum lipid profile of db/db and db/+ mice after 15 weeks of G007-LK treatment.

From: Tankyrase inhibition ameliorates lipid disorder via suppression of PGC-1α PARylation in db/db mice

 

db/db

db/+

Control n = 5 (4)

G007-LK n = 8 (6)

Control n = 9 (6)

G007-LK n = 9 (7)

TC (mmol/l)

2.68 ± 0.25###

1.95 ± 0.14**

1.74 ± 0.08

1.91 ± 0.10

LDL (mmol/l)

0.18 ± 0.04#

0.08 ± 0.01**

0.11 ± 0.01

0.10 ± 0.01

HDL (mmol/l)

0.92 ± 0.03##

0.71 ± 0.06*

0.62 ± 0.03

0.71 ± 0.04

TG (mmol/l)

1.78 ± 0.29###

1.66 ± 0.14

0.89 ± 0.09

0.76 ± 0.05

Glycerol (mmol/l)

0.31 ± 0.02###

0.26 ± 0.03

0.17 ± 0.01

0.18 ± 0.02

NEFA (mmol/l)

1.18 ± 0.19#

0.85 ± 0.12

0.58 ± 0.07

0.66 ± 0.09

  1. Mean ± SEM, n numbers for measuring glycerol are indicated in parenthesis.
  2. TC total cholesterol, LDL low-density lipoprotein cholesterol, HDL high-density lipoprotein cholesterol, TG triglycerides, NEFA nonesterified fatty acids.
  3. *p < 0.05; **p < 0.01 vs. nontreated mice in each group, ###p < 0.001; ##p < 0.01; #p < 0.05 vs. db/+.
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