Table 1 Estimated model parameters for 13C-FFA of lean and obese experiments.

From: Placental mobilization of free fatty acids contributes to altered materno-fetal transfer in obesity

 

vMVM (µmol/min)

vBM (µmol/min)

kaac (1/min)

13C-16:0

Lean

17.1

(± 14.9)

0.008

(± 0.006)

0.65

(± 0.58)

Obese

18.5

(± 26.2)

0.014

(± 0.008)

1.58

(± 2.28)

13C-18:1

Lean

25.5

(± 18.5)

0.132

(± 0.340)

0.54

(± 0.77)

Obese

27.9

(± 51.8)

0.012

(± 0.006)

0.73

(± 1.26)

13C-18:2n6

Lean

16.0

(± 23.3)

0.044

(± 0.107)

0.59

(± 1.05)

Obese

11.9

(± 19.0)

0.005

(± 0.004)

0.34

(± 0.39)

13C-22:6n3

Lean

0.083

(± 0.059)

0.00004

(± 0.00003)

0.86

(± 0.96)

Obese

0.124

(± 0.113)

0.00004

(± 0.00002)

0.34

(± 0.17)

  1. vMVM represents the maximum uptake flux parameter for the MVM (µmol/min); vBM is the maximum flux parameter for the BM (µmol/min); kacc depicts the metabolic accumulation rate constant (1/min). The rate constant krel for metabolic release of labeled fatty acid from the placental tissue is equal to zero and not reported in the table. Mean (± SD) of lean control (n = 8) and obese (n = 7) groups are shown. There are no statistically significant differences between control and obese groups but there was a trend for a difference in 13C-22:6n3 kacc (p = 0.08). Non-parametric group comparison (Mann–Whitney U test) was performed.
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