Fig. 4: Sex and diet influence thermogenic gene expression in mice and humans.
From: Sexual dimorphism in adipose tissue mitochondrial function and metabolic flexibility in obesity
Gene expression of Pgc1a, Ucp1 and Cidea in A BAT and B sWAT of male and female mice fed HFD or STD for 10 weeks. Data are presented as mean ± SEM, differences were considered to be statistically significant at *P < 0.05, **P < 0.01. Human gene expression of C PGC1α, D UCP1 and E CIDEA correlated to BMI. Human females n = 16, human males n = 34. Expression of PGC1α and UCP1 slope of both males and females is not significantly different from zero or each other. Slope of CIDEA expression in males is significantly different from zero (P = 0.0004).
