Table 2 Fasting serum metabolites, HOMA-IR and GTT (AUC) in the offspring at 12 months of age.

From: Effects of maternal diet-induced obesity on metabolic disorders and age-associated miRNA expression in the liver of male mouse offspring

 

CC 12 m

OC 12 m

p value

Triglycerides (mmol L−1)

1.38 ± 0.13

1.06 ± 0.07*

0.0448

Total cholesterol (mmol L−1)

3.20 ± 0.26

4.12 ± 0.3 1

0.0720

HDL (mmol L−1)

1.65 ± 0.13

1.93 ± 0.11

0.2224

LDL (mmol L−1)

0.92 ± 0.15

1.71 ± 0.23*

0.0119

Free fatty acids (µmol L−1)

953 ± 87

798 ± 48

0.1366

Insulin (pmol L−1)

380 ± 55

507 ± 85

0.2266

Leptin (pmol L−1)

4097 ± 332

7181 ± 723**

0.0017

Fasting glucose (mmol L−1)

9.4 ± 0.6

10.0 ± 0.8

0.5153

HOMA-IR

0.13 ± 0.02

0.19 ± 0.03

0.1425

GTT (AUC)

29.7 ± 2.5

29.9 ± 0.8

0.9510

  1. AUC Area Under the Curve, HDL high-density lipoprotein, HOMA-IR Homeostatic Model Assessment for Insulin Resistance, LDL low-density lipoprotein, GTT Glucose Tolerance Test. CC 12 m: mother received control diet and offspring fed control diet after weaning up to 52 weeks of age; OC 12 m: mother received obesogenic diet and offspring fed control diet after weaning up to 52 weeks of age. Values are presented as means ± SEM. CC 12 m: n = 8–9 and OC 12 m: n = 7–9 from independent litters for each group. Data were analyzed by unpaired student’s t test or Mann–Whitney U test. *p < 0.05; **p < 0.01.
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