Table 3 Expression differences of prioritized positional candidate genes between males of the parental lines BFMI 861-S1 (n = 7) and BFMI861-S2 (n = 8). Bold indicates significant differences. The p values are corrected according to Benjamini-Hochberg.
From: Identification of four novel QTL linked to the metabolic syndrome in the Berlin Fat Mouse
QTL name | Chr | Candidate Gene | Type of mutation | FC GonAT (S1/S2) | P value GonAT | FC liver (S1/S2) | P value liver | Gene score |
|---|---|---|---|---|---|---|---|---|
Gatlgq | 17 | Plg | Tolerated domain missense, CTCF binds, enhancer, and promoter variant | 0.12 | 0.23 | 0.02 | 4.66E-03 | 10 |
17 | Acat2 | Deleterious domain missense variant | −0.21 | 7.45E−06 | −0.02 | 0.28 | 9 | |
Gatq1 | 3 | Fmo5 | Tolerated domain missense, UTRs, enhancer, and promoter variant | −0.07 | 3.83E−03 | −0.1 | 9.11E−08 | 12 |
3 | Notch2 | Deleterious domain missense and UTRs variant | 0.05 | 1.29E−03 | −0.06 | 0.02 | 10 | |
Bwq26 | 16 | Trap1 | Tolerated domain missense variant | −0.06 | 5.50E−05 | −0.01 | 0.42 | 7 |
16 | Rrn3 | Tolerated missense variant | −0.08 | 2.05E−06 | −0.12 | 1.28E−06 | 4 | |
Gatq2 | 15 | Trappc9 | UTRs, CTCF binds, enhancer, and promoter variant | −0.06 | 5.89E−05 | −0.07 | 1.92E−04 | 9 |
15 | Zfat | Deleterious domain missense variant | 0.05 | 2.36E−03 | −0.03 | 0.25 | 8 |
