Fig. 4 : Effects of prenatal exposures on childhood overweight through cord blood metabolites and rapid postnatal growth.
a The plot represents on the x-axis the (log) point estimates odds ratio (dots) and 95% confidence intervals (bars) from sequential mediation analysis for the effect of one week increase of gestation on childhood overweight through the cord blood metabolites—grouped in five sets: metabolites previously related with childhood overweight (ov), rapid growth (rg), and rapid growth and childhood overweight (rg and ov) in the MWAS, and with childhood overweight (ob*) and rapid growth (rg*) in the look-up analyses of Handakas et al. [18]—and rapid growth on the y-axis. The analyses are adjusted for sex of the newborns, child ethnicity, cohort membership, child age at the measurement of BMI, maternal education, pre-pregnancy BMI, smoking, age at delivery, and parity. b The simplified directed acyclic graph displays the causal relationships of multiple mediation for one metabolite, cholestenone, in the multiple mediation of gestation age on childhood overweight. CI: confidence intervals, NIE: natural indirect effect; NIEM1: natural indirect effect via M1; NIEM2: natural indirect effect via M2; NDE: natural direct effect; OR: odds ratio, TE: total effect.
