Table 1 Top independent signals associated with BMI identified by the American Indian + GIANT meta-analysis.

From: Identification and characterization of the long non-coding RNA NFIA-AS2 as a novel locus for body mass index in American Indians

   

American Indians (N = 5870)

GIANT (N = 167,425–239,749)

Meta-analysis

Variant

Loci

P/Ra

FreqP

EffectP

P

FreqP

EffectP

P

Phet

P

rs1421085

FTO

T/C

0.85

−0.100

4.6 × 10−4

0.55

−0.075

2.0 × 10−107

0.39

1.1 × 10−73

rs2867110

TMEM18

C/G

0.15

−0.126

1.0 × 10−5

0.12

−0.060

7.5 × 10−46

0.02

3.3 × 10−40

rs1569980

PRKD1

T/C

0.26

−0.082

4.2 × 10−4

0.21

−0.021

9.9 × 10−7

0.009

2.8 × 10−9

rs17522122

AKAP6

G/T

0.61

−0.075

3.8 × 10−4

0.53

−0.016

3.9 × 10−6

0.006

7.6 × 10−9

rs1062557

GRP

C/A

0.69

−0.085

1.7 × 10−4

0.20

−0.017

1.1 × 10−4

0.003

7.8 × 10−8

rs16942379

MAP2K3

T/C

0.32

−0.075

7.2 × 10−4

0.48

−0.016

3.1 × 10−5

0.009

9.7 × 10−8

rs4950106

MIR137HG

G/A

0.17

−0.102

2.2 × 10−4

0.63

−0.012

2.7 × 10−4

0.001

2.2 × 10−7

rs12445430

NLRC3

C/T

0.82

−0.091

6.1 × 10−4

0.81

−0.017

2.0 × 10−4

0.006

3.7 × 10−7

rs1777538

NFIA-AS2

C/T

0.16

−0.117

2.4 × 10−5

0.04

−0.022

4.0 × 10−3

0.0009

5.0 × 10−7

rs9823593

LSAMP

G/C

0.09

−0.119

6.3 × 10−4

0.22

−0.017

3.7 × 10−4

0.004

8.3 × 10−7

rs16943429

RORA

C/T

0.32

−0.093

2.9 × 10−5

0.20

−0.012

8.5 × 10−3

0.0004

1.3 × 10−6

rs17066829

MC4R

T/A

0.45

−0.073

6.3 × 10−4

0.59

−0.012

6.6 × 10−4

0.005

1.4 × 10−6

  1. P values for the American Indian BMI associations were adjusted for age, sex, birth-year, the first five genetic principal components and identity by descent. Meta-analysis was performed using Stouffer’s method based on combining P values.
  2. FreqP frequency of the protective allele, EffectP effect size for the protective allele, Phet the posterior probability of heterogeneity.
  3. aP protective allele for obesity, R risk allele for obesity.
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