Fig. 3: Inflammatory factors downregulate ADIPOQ and APOM gene expression in adipocytes. | International Journal of Obesity

Fig. 3: Inflammatory factors downregulate ADIPOQ and APOM gene expression in adipocytes.

From: Identification of circulating apolipoprotein M as a new determinant of insulin sensitivity and relationship with adiponectin

Fig. 3

Effect of conditioned media from non-polarized, M2-like polarized or M1-like polarized ThP-1 cells on ADIPOQ gene expression in hMADS adipocytes (panel A). Association between ADIPOQ and APOM gene expression in hMADS adipocytes treated for 48 h with conditioned media from non-polarized (gray dots), M2-like polarized (black dots) or M1-like polarized (white dots) ThP-1 cells (panel B). ADIPOQ and APOM gene expression in hMADS adipocytes after C-reactive protein treatment for 48 h (panel C). Association between ADIPOQ and APOM gene expression in hMADS adipocytes treated for 48 h with C-reactive protein (panel D). Results are presented as mean ± SD of 3 independent experiments (panels A and C). Linear correlation coefficients and P-values are displayed in each graph. The dotted lines represent 95% confidence intervals (panels B and D). Data were analyzed by Kruskal–Wallis’ test (panels A and C). *P < 0.05, **P < 0.01.

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