Fig. 2: Effect of weight cycling on metabolic outcomes in C57BL/6 J mice.
From: The metabolic consequences of ‘yo-yo’ dieting are markedly influenced by genetic diversity
a Weight cycling experimental design for 24-week study duration, b group means for body weight over 24 weeks, (c) group means for fat mass over 24 weeks, (d–h) metabolic outcomes at 24 week time point including (d) fasting insulin, (e) insulin at 15 min during glucose tolerance test (GTT), (f) fasting glucose, (g) GTT results and area under the GTT curve, (h) ex-vivo glucose uptake basal (0 nM) and insulin stimulated (10 nM) into adipose tissue. Error bars are SEM. *p < 0.05, **p < 0.01, ***p < 0.001 vs chow, #p < 0.05 vs LOb, $p < 0.05 vs AOb (n = 6–16/group). All statistical analysis was conducted using ANOVA. LOb Later onset obesity, WC Weight cycling, AOb Always having obesity.
