Fig. 3: Effect of weight cycling on metabolic outcomes in DOz mice.
From: The metabolic consequences of ‘yo-yo’ dieting are markedly influenced by genetic diversity
a Experimental design for DOz mice study. Group means over 24 weeks for (b) body weight, (c) fat mass. Group means at 16 weeks time point for (d) fasting glucose, (e) GTT results (f) area under the GTT curve, (g) fasting insulin, (h) insulin at 15 min during GTT. Group means at 24 weeks time point for (i) fasting glucose, (j) GTT results, (k) area under the GTT curve, (l) fasting insulin, (m) insulin at 15 min during GTT. Error bars are SEM. Statistical analysis was conducted using two-sample T-tests for (c, d, f, i, k, l) or Mann–Whitney U-test where groups had unequal variances or outliers (g, h). *p < 0.05, **p < 0.01, ***p < 0.001 (n = 30–32/group). LOb Later onset obesity, WC Weight Cycling.
