Fig. 4: Weight Cycling responses and energy intake in DOz and C57BL/6 J mice.
From: The metabolic consequences of ‘yo-yo’ dieting are markedly influenced by genetic diversity
Fat mass loss (%) following switch from WD to chow for (a) DOz mice and (b) C57BL/6 J mice. Fat mass loss (%) = -(fat mass week 16 - fat mass week 8) / (fat mass week 8 - fat mass week 0). Adjusted weight over 24 weeks in (c) DOz mice and (d) C57BL/6 J mice. Adjusted weight = weight / initial weight (g). Opaque lines are group averages per week, translucent lines are individual values per week. e Experimental design for the DOz mice energy intake study. f Group means over 6 weeks for Average daily energy intake (kcal). Energy intake was measured for 3 consecutive days every 2nd week and averaged to gauge the average daily energy intake per mouse for weeks 2, 4, and 6. Error bars are SEM. NS not significant, *p < 0.05, **p < 0.01, ***p < 0.001 (n = 14–16 / group for C57BL/6 J study, n = 30–32/group for DOz study, n = 19–20 / group for DOz energy intake study). All statistical analysis was conducted using two-sample T-tests. LOb Later onset obesity, WC Weight Cycling.
