Fig. 5: Effect of weight cycling on insulin secretion in C57BL/6 J and DOz mice.
From: The metabolic consequences of ‘yo-yo’ dieting are markedly influenced by genetic diversity
Islet insulin secretion in chow, LOb, WC and AOb C57BL/6 J mice following (a) low dose (2.8 mM) or (b) high dose (16.7 mM) glucose, (c) Homeostasis Model Assessment of beta cell function (HOMA-B) in LOb (orange) and WC (blue) DOz mice, (d) plasma FFA in chow, LOb, WC and AOb C57BL/6 J mice after a 6 h fast, (e) plasma FABP4 levels in chow, LOb, WC and AOb C57BL/6 J mice. All measurements taken at 24 week time point. *p < 0.05, **p < 0.01 vs chow, #p < 0.05 vs AOb, $p < 0.05 vs LOb (n = 6–32/group) Statistical analysis was conducted using ANOVA (a, b, d, e) or Mann–Whitney U-test (c). LOb Later onset obesity, WC Weight cycling, AOb Always having Obesity.
