Table 1 Baseline characteristics of patient cohort.
From: Sex-differential testosterone response to long-term weight loss
Parameter (reference range) | Diet N = 21 | LAGB N = 12 | SG N = 21 | RYGB N = 7 | Total N = 61 | P value |
|---|---|---|---|---|---|---|
All participants | ||||||
Weight (kg)* | 110.9 (26.0) | 105.0 (16.5) | 125.3 (16.9) | 113.1 (15.9) | 115 (22.6) | 0.04 |
BMI, kg/m2*. | 38.1 (6.6) | 37.7 (4.5) | 42.5 (5.3) | 42.3 (7.7) | 40.2 (6.7) | 0.06 |
Age (years)* | 53.4 (8.6) | 42.2 (13.0) | 50.0 (11.7) | 50.9 (7.2) | 50.9 (11.4) | 0.07 |
Cortisol nmol/L, (200–600) | 270 (220, 327) | 284 (249, 306) | 298(203, 368) | 274 (243, 340) | 280 (216, 351) | 0.65 |
ACTH pmol/L, (0–12) | 4.3 (2.7, 5.9) | 4.4 (3.5, 4.62) | 5.2 (2.4, 6.7) | 4.1 (3.6, 5.4) | 4.4 (3.2, 6.2) | 0.44 |
IGF1 nmol/L, (RR 10–30) | 13.1 (10.9, 18.0) | 17.9 (15.2, 19.7) | 12.8 (10.5, 17.6) | 14 (13.8, 16.5) | 14.9 (11.3, 18.7) | 0.41 |
FT4 pmol/L, (RR 11–22) | 14.4 (13.8, 16.5) | 15.3 (14.2, 17.4) | 15.4 (13.9, 16.5) | 15.6 (14.2, 17.6) | 15.2 (13.8, 17) | 0.82 |
FT3 pmol/L, (RR 3–6.2) | 4.5 (4.3, 4.9) | 4.9 (4.5, 5.3) | 5 (4.65, 5.3) | 4.7 (4.35, 5.1) | 4.8 (4.3, 5.3) | 0.08 |
TSH mIU/L, (RR 0.4–4.2) | 2.1(1.3, 3.2) | 1.36 (1.25, 2.3) | 1.5 (1.1, 2.4) | 1.7 (1.4, 2.9) | 1.6 (1.2, 2.6) | 0.01 |
Females | ||||||
Sex (Females), N (%) | 17 (81%) | 10 (83%) | 12 (57%) | 5 (71%) | 44 (72%) | 0.11 |
FSH (IU/L), Postmenopausal Females: (25–140) | 19.7 (5.6, 55) | 9.2 (5.6, 36.4) | 28.8 (4.7, 44.7) | 36.2 (34.7, 58.1) | 27.4 (5.7, 53.6) | 0.90 |
LH (IU/L), Postmenopausal Females: (7.7–60) | 15.2 (6.9, 29.2) | 11.5 (5.2, 28.5) | 14 (5.7, 28.0) | 28 (21.7, 29) | 17.3 (5.7, 30.0) | 0.92 |
Oestradiol pmol/L Postmenopausal Females: <100 | 103 (46, 294) | 127 (84.2, 234) | 74 (59.5, 91) | 72 (49, 76) | 87 (54.2, 218) | 0.72 |
SHBG nmol/L, (20–110) | 34.3 (21.9, 48.9) | 30.0 (24.4, 46.2) | 25.6 (19.6, 106) | 24.7 (20, 27.1) | 29.1 (21.3, 49) | 0.39 |
Testosterone nmol/L, (0.0–1.8) | 0.8 (0.6, 1.25) | 1.15 (0.6, 1.45) | 1.15 (0.75, 1.65) | 0.7 (0.5, 0.8) | 0.9 (0.6, 1.4) | 0.71 |
Males | ||||||
Sexr (Males), N (%) | 4 (19%) | 2 (17%) | 9 (43%) | 2 (29%) | 17 (28%) | |
FSH (IU/L), Males (1.5–13) | 6.45 (5.6, 7.4) | 4.7 (4.5, 4.95) | 3.7 (3.0, 4.5) | 4.7 (4.7, 4.7) | 4.2 (3.7, 6.3) | 0.32 |
LH (IU/L), Males: (1.7–8.6) | 5.4 (4.9, 6.55) | 2.65 (2.6, 2.7) | 3.7 (2.5, 4.4) | 5.6 (5.6, 5.6) | 4.0 (2.7, 5.3) | 0.12 |
Oestradiol pmol/L, (0–160) | 85 (76.5, 93.5) | 126 (125, 128) | 93 (78, 132) | 162 (162, 162) | 113 (80.5, 131) | 0.27 |
SHBG nmol/L, (20–90) | 20.1 (17.9, 24) | 25.5 (21.2, 29.8) | 24.5 (16.6, 30.8) | 17 (17, 17) | 20.1 (17, 31.6) | 0.56 |
Testosterone nmol/L, (12–36) | 13.7 (9.95, 17.2) | 18.2 (15.0, 21.5) | 11.8 (9.5, 13.7) | 11.7 (11.7, 11.7) | 11.8 (10.1, 16.4) | 0.91 |
