Fig. 1: Weight change 6 months after prescription of incretin-based weight loss medications by categories of second-generation antipsychotics.

Associations (95% robust confidence intervals) are adjusted for baseline weight and duration of follow-up for prescription of incretin-based weight loss medications (semaglutide or tirzepatide). Second-generation antipsychotics were categorized based on their propensity for inducing weight gain as high (olanzapine, clozapine) intermediate (risperidone, quetiapine, paliperidone) and low (others). Panel A Weight (kg), Panel B Weight (percentage points), Panel C Risk ratio for 5% weight loss.