Fig. 1: Effects of GLP1 analogs on body weight, food intake, liver and heart weight.

A Body weight change for 21 days. B Food intake change for 19 days. C Percentage change in body weight from before to after 21 days of treatment. D Cumulative food intake over a 19-day period. Liver and heart weight (E–F). Data are represented as the mean ± SD from five mice in each group. Data are represented as the mean ± SD from 5 mice per group, 3 mice in the tirzepatide-treated group only. Statistical analysis in (a), (b) were done using Student’s t-test or Tukey test followed by Bonferroni’s correction. Statistical analysis for (c)-(d) was done using Student’s t-test or Tukey’s test. #p < 0.05, ##p < 0.01, vs Normal group by Student’s t-test, *p < 0.05, **p < 0.01, vs Vehicle or Semaglutide group by Tukey’s test.