Fig. 2: Changes in body weight and body composition after treatment with GLP-1 analogs.

Body weight (A), Fat and lean mass (B–C). Scout image of mice whole body scanned by X-ray CT. Cross-sectional image of the peri-abdominal area imaged by X-ray CT. D Quantitative evaluation value of visceral and subcutaneous fat from segmental CT images E. Correlation of visceral fat mass (F) and subcutaneous fat mass (G) with total fat mass were calculated. Data are represented as the mean ± SD from 5 mice per group, 3 mice in the tirzepatide-treated group only. Statistical analysis was done using Student’s t-test or Tukey’s test. #p < 0.05, ##p < 0.01, vs Normal group by Student’s t-test, *p < 0.05, **p < 0.01, vs Vehicle group by Tukey’s test.