Fig. 1

Family pedigree and pedigree-based linkage study of affected and unaffected individuals. The segregating haplotype is indicated by a box with seven polymorphic microsatellite markers on 4q13.1-4q21.1. AMBN is flanked by D4S2969 and D4S1543. Affected subjects are denoted in black. The proband is indicated by an arrow.