Table 2 Proteases detected in saliva from patients with various oral diseases

From: Salivary protease spectrum biomarkers of oral cancer

Item

Healthy

JBO

CPD

OSCC

  

ADAM8

ADAM8

ADAM8

   

ADAM9

ADAM9

   

ADAMTS1

ADAMTS1

    

ADAMTS13

 

Cathepsin A

Cathepsin A

Cathepsin A

Cathepsin A

 

Cathepsin B

Cathepsin B

Cathepsin B

Cathepsin B

 

Cathepsin C

Cathepsin C

Cathepsin C

Cathepsin C

 

Cathepsin D

Cathepsin D

Cathepsin D

Cathepsin D

    

Cathepsin E

Positive proteases

Cathepsin S

Cathepsin S

Cathepsin S

Cathepsin S

 

Cathepsin V

Cathepsin V

Cathepsin V

Cathepsin V

 

Cathepsin X/Z/P

Cathepsin X/Z/P

Cathepsin X/Z/P

Cathepsin X/Z/P

 

DPPIV/CD26

DPPIV/CD26

DPPIV/CD26

DPPIV/CD26

 

Kallikrein 5

Kallikrein 5

Kallikrein 5

Kallikrein 5

 

Kallikrein 6

Kallikrein 6

Kallikrein 6

Kallikrein 6

   

Kallikrein 7

Kallikrein 7

 

Kallikrein 10

Kallikrein 10

Kallikrein 10

Kallikrein 10

 

Kallikrein 11

Kallikrein 11

Kallikrein 11

Kallikrein 11

 

Kallikrein 13

Kallikrein 13

Kallikrein 13

Kallikrein 13

    

MMP-1

    

MMP-2

    

MMP-3

   

MMP-7

MMP-7

 

MMP-8

MMP-8

MMP-8

MMP-8

 

MMP-9

MMP-9

MMP-9

MMP-9

    

MMP10

   

MMP-12

MMP-12

    

MMP-13

   

Neprilysin/CD10

Neprilysin/CD10

   

uPA/Urokinase

uPA/Urokinase

 

Proprotein convertase 9

Proprotein convertase 9

Proprotein convertase 9

 
 

Proteinase 3

Proteinase 3

Proteinase 3

 

Total

17(48.6%)

18(51.4%)

25(71.4%)

30(85.7%)

  1. JBO jaw bone ossification fibroma, CPD chronic periodontitis, OSCC oral squamous cell carcinoma, ADAM A disintegrin and metalloprotease, ADAMTS a disintegrin and metalloproteinase with thrombospondin motifs, MMP matrix metalloproteinases, uPA urokinase-type plasminogen activator