Table 4 AUC, cutoff point, sensitivity and specificity of MMP-1, ADAM9, cathepsin V and kallikrein 5 in the diagnosis of OSCC

From: Salivary protease spectrum biomarkers of oral cancer

Proteases

AUC

95%CI

P

Cutoff point

Sensitivity

Specificity

MMP-1

0.703

0.563--0.843

0.007

199

0.8

0.617

ADAM9

0.747

0.621--0.873

0.001

202.55

0.45

0.767

Cathepsin V

0.776

0.777--0.875

0

11.34

0.6

0.8

Kallikrein 5

0.843

0.743--0.942

0

9.29

0.7

0.867 7

M1A9CvK5

0.963

0.872--1.0

0

 

0.85

0.933

M1A9Cv

0.821

0.843--0.999

0

 

0.7

0.867

M1A9K5

0.873

0.773--0.974

0

 

0.65

1

M1CvK5

0.926

0.858--0.994

0

 

0.65

1

A9CvK5

0.938

0.873--1.0

0

 

0.9

0.991 7

  1. ADAM a disintegrin and metalloprotease, MMP matrix metalloproteinases, AUC area under curve, CI confidence interval, M1A9CvK5 MMP-1/ADAM9/Cathepsin v/Kallikrein 5, M1A9Cv MMP-1/ADAM9/Cathepsin v, M1A9K5 MMP-1/ADAM9/Kallikerin5, M1CvK5 MMP-1/Cathepsin v /Kallikrein 5, A9CvK5 ADAM9/Cathepsin v/Kallikrein
Back to article page