Fig. 2

GO enrichment analysis of the metatranscriptome profiles of the oral microbiome associated with cancer status; over-represented biological processes. Enriched terms obtained using GOseq were summarised and visualised as a scatter plot using REVIGO. a Summarised GO terms in healthy control tumour-matched sites vs OSCC tumour sites. b Summarised GO terms in OSCC tumour-adjacent sites vs OSCC tumour sites. c Summarised GO terms in OSCC tumour-adjacent sites vs buccal sites from healthy control patients. Bubble size indicates the frequency of the GO term in the underlying GO database. Colour indicates the log10 P-value (red higher, green lower) showing the significance of GO enrichment for a particular GO term. The X and Y axes represent semantic spaces that have no intrinsic meaning. REVIGO uses multi-dimensional scaling to reduce the dimensionality of a matrix of the GO terms’ pairwise semantic similarities. The results with semantically similar GO terms remain close together in the plot. Semantic similarity between two GO terms is based on the shared proteins contained in those terms