Table 3 Bacteria with known functional riboflavin biosynthesis pathways

From: Mucosal-associated invariant T cells and oral microbiome in persistent apical periodontitis

Phylum

Family or genus

Prevalence in AP lesions/%

Prevalence in control tissues/%

Actinobacteria

Corynebacterium

42.9

50.0

Bacteriodetes

Bacteroides

3.6

0.0

 

Prevotella

57.1

67.9

 

Rikenellaceae

25.0

10.7

Firmicutes

Streptococcus

57.1

78.6

 

Anaerococcus

10.7

14.3

 

Erysipelotrichaceae

3.6

3.6

Fusobacteria

Fusobacterium

71.4

75.0

Proteobacteria

Ralstonia

14.3

17.9

 

Bilophila

3.6

0.0

 

Desulfovibrio

7.1

0.0

 

Campylobacter

39.3

42.9

 

Enterobacteriaceae

85.7

82.1

 

Acinetobacter

3.6

3.6

Synergistetes

Fretibacterium

42.9

39.3

  1. All AP lesions and control tissue contained multiple bacterial taxa that are predicted to have functional riboflavin biosynthesis pathways, specifically containing a 6,7-dimethyl-8-ribityllumazine (RL-6,7-diMe) synthase gene (EC 2.5.1.78) required for the production of the main MR1-binding ligand RL-6,7-diMe11,52