Table 2 Candidate genes and related dental caries outcomes

From: Human genes influence the interaction between Streptococcus mutans and host caries susceptibility: a genome-wide association study in children with primary dentition

Outcome

SNP

CHR

EA

Location

EAF

P total

Coeff total

P discovery

Coeff discovery

P validation

Coeff validation

Gene

Dmft

rs11635005

15

T

Intronic

0.2

0.0001

−0.7

5.2 × 10−5

−1.33

0.004 8

−1.11

GALK2

Dmft

rs4786370

16

C

Upstream 2 kb

0.42

<0.0001

0.76

8.3 × 10−5

1.06

0.001

1.15

IL32

Dmft

rs1539849

18

C

Intronic

0.7

0.0001

−0.63

1.9 × 10−5

−1.28

0.046 8

−0.82

CELF4

Dmftw

rs1539849

18

C

Intronic

0.7

0.0001

−0.63

8 × 10−6

−1.32

0.046 8

−0.82

CELF4

  1. Total means the value obtained from the entire sample. Discovery means the value obtained at the discovery stage. Validation means the value obtained at the validation stage
  2. CHR, chromosome; EA, effective allele; EAF, effective allele frequency; Coeff, coefficient of the interaction
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