Fig. 1 | International Journal of Oral Science

Fig. 1

From: Disturbed bone remodelling activity varies in different stages of experimental, gradually progressive apical periodontitis in rats

Fig. 1

Bone remodelling is disturbed in the periapical region of human apical periodontitis. a–d Representative images of histological and immunohistochemistry staining with the indicated antibodies on serial sections of human apical region tissue from patients without (control) or with chronic apical periodontitis. a H&E staining shows lining cells (grey asterisk), adipose tissue (blue asterisk) in the control and increased blood vessels and decreased bone tissue in apical periodontitis tissue. b Masson’s trichrome staining shows increased collagen fibres (pink arrow). c TRAP staining shows decreased osteoclasts (grey arrow). d Immunohistochemical staining of Osx shows increased osteoblasts (blue arrow) surrounding the blood vessels (green dotted lined area). The magnified framed region is shown below. Bone tissue (black asterisk), blood vessels (green asterisk); scale bar: 100 µm

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