Fig. 5: Chronic TNFα exposure decreases stemness-inhibiting miRNAs in HPV-immortalized cells and E6-expressing cells. | International Journal of Oral Science

Fig. 5: Chronic TNFα exposure decreases stemness-inhibiting miRNAs in HPV-immortalized cells and E6-expressing cells.

From: Proinflammatory cytokine TNFα promotes HPV-associated oral carcinogenesis by increasing cancer stemness

Fig. 5

a Differentially expressed stemness-inhibiting miRNAs (i.e., miR-203, miR-200a, miR-200b, miR-200c, miR-141, miR-429) in microarray data were validated by qPCR using HOK-16B and 16B/TNF cells. Levels of miRNAs were normalized to the expression of U6 snRNA. *P < 0.01 and **P < 0.05. b Levels of the stemness-inhibiting miRNAs were compared in the OKF6/tert cells expressing E6 and E6/TNF cells. c Levels of the stemness-inhibiting miRNAs were compared in the OKF6/tert cells expressing E7 and E7/TNF cells.

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