Fig. 3 | International Journal of Oral Science

Fig. 3

From: Human β-defensin 3 gene modification promotes the osteogenic differentiation of human periodontal ligament cells and bone repair in periodontitis

Fig. 3

The role of the p38 MAPK pathway in the osteogenic differentiation of the hPDLCs after Ad-hBD3 transfection in an inflammatory environment. hPDLCs were transfected with Ad-hBD3 or NC (Ad-GFP) and all were treated with E. coli LPS (1 μg·mL−1). a p38 and p-p38 expression in the hPDLCs on day 3, b ALP staining and ALP activity on day 7, c alizarin red S staining of the mineralized nodules on day 21. d, e Bone-related gene and protein expression after adding SB203580 (**P < 0.01, ***P < 0.001)

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