Fig. 3 | International Journal of Oral Science

Fig. 3

From: PKD3 promotes metastasis and growth of oral squamous cell carcinoma through positive feedback regulation with PD-L1 and activation of ERK-STAT1/3-EMT signalling

Fig. 3

PKD3 overexpression can promote the proliferation, migration and invasion of OSCC cells. a Growth curves. b Transwell migration assay with DOKs and Cal-27 cells transfected with pCDNA3.1/NT-PKD3 (OE-PKD3) or control plasmid (Con). The number of migrated cells per field is shown in the bar graphs; scale bar size = 50 µm. c Transwell invasion assay for the indicated cell lines. The number of invading cells per field is shown in the bar graphs; scale bar size = 50 µm. Nuclei were stained with DAPI (blue). Red represents the cytoskeleton labelled with 555 phalloidin. Data are presented as the means ± SD (n = 3). *P < 0.05; **P < 0.01; ***P < 0.001. PKD3, protein kinase D3; OSCC, oral squamous cell carcinoma

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