Fig. 4 | International Journal of Oral Science

Fig. 4

From: PKD3 promotes metastasis and growth of oral squamous cell carcinoma through positive feedback regulation with PD-L1 and activation of ERK-STAT1/3-EMT signalling

Fig. 4

The role of PKD3 in the EMT phenotype of OSCC induced by the PD-1/PD-L1 pathway. a, b Western blotting was used to detect the levels of PKD3, PD-L1 and EMT markers in Cal-27 cells treated with the PD-1 fusion protein. c, d Protein levels of PKD3, PD-L1 and EMT markers after stable knockdown of PKD3 in Cal-27 cells cultured in the presence or absence of PD-1 fusion protein. Data are presented as the means ± SD (n = 3). *P < 0.05; **P < 0.01; ***P < 0.001; ns, nonsignificant; PKD3, protein kinase D3; OSCC, oral squamous cell carcinoma; PD-1, programmed cell death protein 1; PD-L1, programmed death ligand-1; EMT, epithelial–mesenchymal transition

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