Fig. 7 | International Journal of Oral Science

Fig. 7

From: PKD3 promotes metastasis and growth of oral squamous cell carcinoma through positive feedback regulation with PD-L1 and activation of ERK-STAT1/3-EMT signalling

Fig. 7

PKD3 promotes the growth and lymph node metastasis of OSCC cells in vivo. a Immunohistochemical staining of PKD3 and PD-L1 in subcutaneous footpad tumours. Black scale bars are 50 m. b Nude mouse footpads were inoculated with Cal-27 Con, sh-PKD3-1 and sh-PKD3-2 cells. Four weeks later, subcutaneous tumours of the footpads were collected, and their volumes were measured. c Immunohistochemical staining of GFP was used to evaluate the ratio of metastatic lymph nodes among different groups; scale bar size = 30 m. d Popliteal lymph nodes volumes. Data are presented as the means SD (n = 9 per group). **P < 0.01; ***P < 0.001. PKD3, protein kinase D3; PD-L1, programmed death ligand-1; OSCC, oral squamous cell carcinoma; LNs, lymphnodes; GFP, green fluorescent protein

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