Fig. 8 | International Journal of Oral Science

Fig. 8

From: PKD3 promotes metastasis and growth of oral squamous cell carcinoma through positive feedback regulation with PD-L1 and activation of ERK-STAT1/3-EMT signalling

Fig. 8

The prediction model of the PKD3/PD-L1 positive feedback loop. PKD3/PD-L1 drives EMT through ERK/STAT1/3 signalling, thus promoting tumour growth and metastasis. PKD3, protein kinase D3; ERK, extracellular signal-regulated kinase; STAT, signal transducer and activator of transcription; PD-L1, programmed death ligand-1; PD-1, programmed cell death protein 1

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