Fig. 1
From: PER2-mediated ameloblast differentiation via PPARγ/AKT1/β-catenin axis
Decreased enamel matrix secretion and cytoskeletal molecules expression in the neonatal offspring of pregnant mice with circadian disruption. An environmental circadian disruption model was constructed in 10- to 12-week-old pregnant mice. a The mandibles of the offspring (PN5) were dissected. Compared to the control group, the enamel matrix secretion decreased (shown as black arrows), and there were some obvious voids (shown as black asterisks) among ameloblasts of mandibular incisor germs in the disturbance group. Bar = 20 μm; sa secretory ameloblast, e enamel, d dentin, od odontoblast, dp dental pulp. b Compared to the control group, the expression levels of CK14 and F-actin were reduced in ameloblasts, especially in Tomes’ processes in the disturbance group (shown as white arrows in the Con group and white asterisks in the disturbance group). Original magnification, ×100
