Fig. 6
From: PER2-mediated ameloblast differentiation via PPARγ/AKT1/β-catenin axis
Overexpression of PPARγ reversed β-catenin subcellular localization in Per2-knockdown ALC cells. ALC-Con and ALC-Per2-sh were transfected with plasmids. a, b In the differentiation assay, the expression of β-catenin was obviously decreased in the nucleus (a) and cytoplasm (b) in ALC-Per2-sh-pEnCMV-Pparγ cells. c Cell immunofluorescence showed that β-catenin translocated into the nucleus in ALC-Per2-sh-pEnCMV cells compared with ALC-Con-pEnCMV cells but was reversed in ALC-Per2-sh-pEnCMV-Pparγ cells. *P < 0.05; **P < 0.01; ***P < 0.001
