Fig. 7 | International Journal of Oral Science

Fig. 7

From: Exosomes derived from 3D-cultured MSCs improve therapeutic effects in periodontitis and experimental colitis and restore the Th17 cell/Treg balance in inflamed periodontium

Fig. 7

mir-1246 antagomir reversed the effects of 3D-exos, reducing the ratio of Th17 cells to Treg cells in both the inflamed gingiva and colon. a–d Flow cytometric profiles of Foxp3 and IL-17 expression in CD4+ cells in the inflamed gingiva of PBS-, 3D-exo– and 3D-exo+ antagomir 1246-treated groups. Numerical values denote the mean percentage of CD4+ cells expressing Foxp3 and IL-17 in each group (n = 6). The error bars represent the SEM. *P < 0.05. e–h Flow cytometric profiles of Foxp3 and IL-17 expression in CD4+ cells in the inflamed colon of the PBS-, NCI-3D-exo-, and miR1246I-3D-exo-treated groups. Numerical values denote the mean percentage of CD4+ cells expressing Foxp3 and IL-17 in each group (n = 6). The error bars represent the SEM. *P < 0.05

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