Fig. 6
From: Four-Octyl itaconate ameliorates periodontal destruction via Nrf2-dependent antioxidant system
Inhibition of Nrf2 impairs the 4-OI mediated antioxidant protective effect and the therapeutic effect on inflammatory periodontal microenvironment. a Micro-CT image of the alveolar bone. The red part displayed the exposure of root. CEJ-ABC distance (b), BV/TV (c), and Tb. Th (d). e–i Representative images of histological analysis in periodontal tissue. (Scale bar = 400, 100, or 25 µm). j, k The semi-quantitative analysis of TRAP staining and IHC staining of Nrf2. l Illustration of local injection of 4-OI in experimental periodontitis Nrf2−/− mice for 14 days. Data are presented as the mean ± SD. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.000 1. Lig ligature, ab alveolar bone, R root, sMaf small musculoaponeurotic fibrosarcoma
