Fig. 7 | International Journal of Oral Science

Fig. 7

From: MSCs-derived apoptotic extracellular vesicles promote muscle regeneration by inducing Pannexin 1 channel-dependent creatine release by myoblasts

Fig. 7

Creatine promotes C2C12 myoblasts fusion in vitro. a–d The representative immunofluorescence images of myosin staining of C2C12 myoblasts in control and creatine-treated groups with or without Z-VAD exist (a, c). The analysis of fusion index of C2C12 myoblasts in different treated groups (b, d). e, f The representative immunofluorescence images and analysis of fusion index of C2C12 myoblasts in control and Pannexin 1 inhibitor BB-FCF treated groups. g, h The representative immunofluorescence images and analysis of fusion index of C2C12 myoblasts in control and BB-FCF and MSCs-ApoEVs treated groups; n = 3 per group; data were shown as mean ± SD; ns not significant, the scale bar indicates 20 μm; *P < 0.05, **P < 0.01, ***P < 0.001

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