Fig. 1 | International Journal of Oral Science

Fig. 1

From: Porphyromonas gingivalis bacteremia increases the permeability of the blood-brain barrier via the Mfsd2a/Caveolin-1 mediated transcytosis pathway

Fig. 1

Porphyromonas gingivalis (P. gingivalis) bacteremia enhanced the blood–brain barrier (BBB) permeability in rats. a Evans blue staining was used to detect BBB permeability. b Western blot and quantification showed Albumin protein deposition in the hippocampus (I and II) and the cortex (III and IV) in the rat brain tissues with P. gingivalis bacteremia. *P < 0.05, **P < 0.01, ***P < 0.001 when compared to the control group. Values are expressed as the mean ± standard deviation. c Immunofluorescence showed Albumin (green) protein deposition increased both in the hippocampus and in the cortex of the rat brain with P. gingivalis bacteremia. Low: the low-intensity group. High: the high-intensity group. Scale bar, 500 μm. The results represent three independent experiments

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