Fig. 6 | International Journal of Oral Science

Fig. 6

From: Porphyromonas gingivalis bacteremia increases the permeability of the blood-brain barrier via the Mfsd2a/Caveolin-1 mediated transcytosis pathway

Fig. 6

Porphyromonas gingivalis (P. gingivalis) significantly inhibited Mfsd2a expression. a RT-qPCR showed that P. gingivalis inhibited Mfsd2a gene expression in brain microvascular endothelial cells (BMECs). b Western blot (I) and quantification (II) showed Mfsd2a protein expression decreased in BMECs infected with P. gingivalis for 24 h. c Confocal laser microscopy revealed that Mfsd2a expression (green) in the microvasculature co-localized with CD31 (red) in the rat brain tissues with P. gingivalis bacteremia was sigificantly lower than that in the control group both in hippocampus and cortex tissues. I: Representative images of confocal laser microscopy in hippocampus. II: Representative images of confocal laser microscopy in cortex tissues. Scale bar, 50 μm. High: the high-intensity group. The results represent three independent experiments. *P < 0.05, **P < 0.01 when compared to the control group

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