Table 1 Cementum and pre-dentin parameters from H&E stained sections

From: Sclerostin antibody improves alveolar bone quality in the Hyp mouse model of X-linked hypophosphatemia (XLH)

Variable

WT Vehicle

WT Scl-Ab

Hyp Vehicle

Hyp Scl-Ab

Genotype

Treatment

Interaction

Males

Acellular Cementum Thickness/μm

5.22 ± 1.78

5.79 ± 1.54

1.94 ± 0.44b

1.57 ± 0.45b

<0.001

0.852

0.369

Pre-Dentin Thickness/μm

4.48 ± 1.04

3.85 ± 2.14

12.37 ± 3.89b

11.36 4.68b

<0.001

0.538

0.887

Cellular Cementum Area/mm2

0.15 ± 0.08

0.17 ± 0.03

0.15 ± 0.01

0.16 ± 0.04

0.827

0.630

0.933

Females

Acellular Cementum Thickness/μm

5.91 ± 1.91

5.27 ± 1.66

2.80 ± 1.04b

1.72 ± 0.63b

<0.001

0.147

0.711

Pre-Dentin Thickness/μm

4.34 ± 2.83

4.51 ± 2.98

7.33 ± 1.55

7.14 ± 2.28

0.018

0.992

0.870

Cellular Cementum Area/mm2

0.17 ± 0.08

0.16 ± 0.02

0.13 ± 0.01

0.17 ± 0.08

0.564

0.648

0.281

  1. Sample sizes for each variable are as follows:
  2. Acellular Cementum - n = 5, 6, 6, 5 for male WT+vehicle, WT+Scl-Ab, Hyp+vehicle, Hyp+Scl-Ab and n = 6, 6, 5, 7 for female WT+vehicle, WT+Scl-Ab, Hyp+vehicle, Hyp+Scl-Ab
  3. Pre-Dentin Thickness - n = 6, 7, 6, 3 for male WT+vehicle, WT+Scl-Ab, Hyp+vehicle, Hyp+Scl-Ab and n = 6, 5. 3, 3 for female WT+vehicle, WT+Scl-Ab, Hyp+vehicle, Hyp+Scl-Ab
  4. Cellular Cementum Area - n = 3, 4, 3, 3 for male WT+vehicle, WT+Scl-Ab, Hyp+vehicle, Hyp+Scl-Ab and n = 4, 5, 5, 3 for female WT+vehicle, WT+Scl-Ab, Hyp+vehicle, Hyp+Scl-Ab
  5. aIndicates significant differences between vehicle and Scl-Ab-treated mice of the same genotype
  6. bIndicates significant differences from vehicle treated WT mice
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