Fig. 5
From: PRX1-positive mesenchymal stem cells drive molar morphogenesis
PRX1-positive stem cells functioned primarily through Wnt5a-mediated Wnt signaling pathway. a VinPlot displayed the comprehensive expression profiles of all non-canonical Wnt ligands Wnt5a, Wnt5b, Wnt11 and highly expressed receptor Fzd2 within varied cell clusters at cap stage (E14.5). The red boxes mark the mesenchymal subsets with high Wnt5a expression. b CellChat analysis of intercellular communication network of non-canonical Wnt signaling pathway at cap stage (E14.5). c CellChat analysis of intercellular communication network of Wnt5a-Fzd2 signaling pathway at E14.5. d UMAP and VinPlot visualization of Wnt5a expression and its correlation with Prx1 at E14.5. e Dotplot of Prx1 and Wnt5a in tooth germs at bud stage (E13.5), cap stage (E14.5) and bell stage (E16.5). Wnt5a had a large overlap with the PRX1+ mesenchymal cell subsets
