Fig. 2

PD alters both oral and lung microbiota in hypoxia-induced PH mice. a, b Chao1, Faith’s phylogenetic diversity (Faith’s) and Observed species of microbiota in oral ligature a and lungs b. n = 5 per group. c, d Principal coordinate analysis (PCoA) of microbiota in oral ligature c and lungs d. n = 5 per group. e, f Random Forest regression analysis of oral e and lung f microbiota. Identified species were ranked by importance and relative abundance of the indicated species in oral ligatures and lungs. n = 5 per group. g, h Relative abundance of Prevotella zoogleoformans (P. zoogleoformans) in oral ligatures g and lungs h. n = 5 per group. i Fluorescence in situ hybridization for P. zoogleoformans in lung sections. Data are presented as mean ± SEM. Student’s t test g, h was used for statistical analysis. *P < 0.05. **P < 0.01