Fig. 3
From: Periodontitis exacerbates pulmonary hypertension by promoting IFNγ+ T cell infiltration in mice
P. zoogleoformans exacerbates PH in mice. a Schematic illustration of the experimental design. b, c RVSP b and Fulton index c determined by the ratio of (RV/(LV + S)). n = 6:6 for RVSP, n = 8:5 for Fulton index. d, e Representative echocardiography images d and measurements of PA function by PAT/PET ratio e after exposure to hypoxia for 3 weeks. n = 10:9. f Representative WGA staining of RV sections. g Quantification of RVCM area based on WGA staining. n = 8:7. h Representative H&E staining and immunofluorescence staining of α-SMA of lung sections. i Quantification of medial thickness as a percentage of external diameter of PAs. n = 7:5. j Quantification of α-SMA+ area as a percentage of cross-sectional area (CSA) of PAs. n = 6:7. k Fluorescence in situ hybridization for P. zoogleoformans in lung sections. Pz, ligature-induced periodontitis with oral infection of P. zoogleoformans. Data are presented as mean ± SEM. Student’s t test (b, c, e, g, i, j) was used for statistical analysis. *P < 0.05
