Fig. 7
From: Periodontitis exacerbates pulmonary hypertension by promoting IFNγ+ T cell infiltration in mice
Working model illustrating the mechanisms that mediate the aggravation of pulmonary hypertension (PH) by periodontitis. Periodontitis aggravates PH through an oral-lung axis. The specific mechanisms include: (1) oral pathogen P. zoogleoformans induces the expansion of IFNγ+ T cells in cervical lymph nodes (cLNs), and (2) periodontitis facilitates the translocation of P. zoogleoformans to the lungs, leading to increased infiltration of IFNγ+ T cells in the lung. RVSP, right ventricular systolic pressure
