Fig. 2 | International Journal of Oral Science

Fig. 2

From: Integrative single-cell and bulk transcriptomes analyses reveals heterogeneity of serine-glycine-one-carbon metabolism with distinct prognoses and therapeutic vulnerabilities in HNSCC

Fig. 2

SGOC metabolism is upregulated and correlated with poor prognosis in HNSCC. a UMAP plots of epithelial cells in HNSCC samples colored by cell type (GSE181919). b Venn diagram of differentially expressed metabolic pathways identified by scRNA-seq and bulk-seq profiles (TCGA-HNSC). c Heatmap of differentially expressed metabolic pathways identified by scRNA-seq. d Sketch map of SGOC metabolic network. e UMAP plots of epithelial cells colored by SGOC cores. f Violin diagram showed the scores of SGOC metabolic pathways between non-malignant and malignant cells of scRNA-seq. g Univariate Cox analysis of the correlations between SGOC metabolic network and overall survival of HNSCC patients in TCGA-HNSC cohort. h Kaplan–Meier curves of overall survival (OS) according to SGOC scores in TCGA-HNSC cohort. *P < 0.05

Back to article page